
01ELLEN POMPEO
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/ellen-pompeo2-2000-25a9e9601eb24efebd295312d7f5c229.jpg)
Pompeo has starred as Meredith Grey since the show’s pilot episode, which first aired in 2005.
CHANDRA WILSON
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/chandra-wilson1-2000-716002e6bb70439b97910978f4a9d7eb.jpg)
Miranda Bailey made her first-ever Grey’s appearance in the pilot episode.
JUSTIN CHAMBERS
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/justin-chambers1-2000-2d05f26135d6415eb4e98ac9b5414269.jpg)
Chambers also first appeared in the pilot episode as Alex Karev.
JAMES PICKENS, JR.
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/james-pickens-jr-2000-2d1f8be503c948a29875a6a3165de60c.jpg)
The actor appeared in the show’s pilot episode as Seattle Grace’s chief.
KEVIN MCKIDD
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/kevin-mckidd1-2000-eced6d165d3345d59928763f3078cfeb.jpg)
McKidd’s Owen Hunt was welcomed by the Grey’s crew in the season 5 premiere in 2008.
JESSICA CAPSHAW
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/jessica-capshaw1-2000-7c7e3bd4567a4ea2b3c62a58fd884217.jpg)
Season 5, episode 11 saw Capshaw take on the role of Arizona Robbins.
SARAH DREW
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/sarah-drew-2000-d2c78bda6edd4d8094b95ff8a058e916.jpg)
Drew’s April Kepner made her Grey’s debut in season 6, episode 5.
JESSE WILLIAMS
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/jesse-williams1-2000-978eeb207f9f40be91bacc8e6025d096.jpg)
Williams’ Jackson Avery also joined the team of doctors in season 6.
CATERINA SCORSONE
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/caterina-scorsone1-2000-7b0b43b5e1694d71ab51c69a99cf1fcd.jpg)
Though Amelia Shepherd made her debut in season 3, she became a series regular starting in season 10.
CAMILLA LUDDINGTON
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/camilla-luddington-2000-e3ef1f6babc646dfb00ad539c8b9d4ef.jpg)
Fans followed Jo Wilson’s journey as an intern in season 9.
KELLY MCREARY
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/kelly-mccreary-2000-1387f8da9ca546bab18fc1d9464adb2c.jpg)
McCreary’s Maggie Pierce first made her debut in season 10, episode 23.
GIACOMO GIANNIOTTI
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/giacomo-gianniotti-2000-eeefc40af6c049ae98fc3fd161b27552.jpg)
The actor’s character, Andrew DeLuca, said hello to Grey’s audiences in season 11, episode 24.
JASON GEORGE
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/jason-george-2000-295e5f5e584948e6a5a66fa102a525bd.jpg)
Benjamin Warren first made his debut in season 6, episode 13.
MARTIN HENDERSON
:max_bytes(150000):strip_icc():focal(999x0:1001x2):format(webp)/martin-henderson-2000-18bd59dcd68444b9823762afb92368a8.jpg)
Season 12, episode 6 served as Nathan Riggs’ (Henderson) debut. He stayed on until season 14.