
Calliope Torres first appeared in Grey’s Anatomy in early 2006 during the Season 2 episode titled “What Have I Done to Deserve This?” Callie joined the group as an ortho goddess, introduced to help fix George O’Malley’s dislocated shoulder. With that said, though, she also showed up as a love interest for George. Callie was a bit of an outcast compared to the rest of the group, but it’s nearly impossible for Grey’s fans not to love her energy. Soon after her relationship with George ended, the show started to explore Callie’s sexuality, pairing her with McSteamy and introducing her to cardiothoracic attending Erica Hahn. Callie and Erica go from friends to lovers to strangers as Callie discovers she’s bisexual. Not long after the harsh and no-nonsense blonde ghosted Callie, a new blonde literally rolled into Callie’s life with a brand new joyful and playful energy.
Updated on July 10, 2024 by Katie Doll: Callie and Arizona have been through it all on Grey’s Anatomy. From a long-distant relationship to affairs, to tragic accidents, the soulmates eventually had to call it quits at the end of their run. This article has been updated with any new information about Calzona since Arizona’s return to Grey’s Anatomy in Season 20.
Callie and Arizona’s Relationship Timeline
Callie and Arizona Met in Season 5
They Weren’t Official, But the Ship Launched

While Meredith Grey and Nick Marsh reconciled in the Grey’s Anatomy Season 19 finale, whether or not their relationship lasts is still unclear.
- Notable Episodes: 11, 14, and 20
Callie was understandably intrigued by Arizona after their meeting, but the blonde squashed any hopes for a relationship. Essentially, Arizona didn’t want to waste any time or energy on a relationship with Callie because Callie was still discovering her sexuality. Luckily, the apprehension didn’t last very long, as the end of the season featured their first dates.
Callie and Arizona’s Relationship Began in Season 6
It Was a Rocky Start, but Their Chemistry Was Powerful
- Notable Episodes: 1, 3, 5, 6, 12, 17, 18, and 21
Season 6 started with Callie and Arizona in the early stages of their relationship, but they were both happy, and the chemistry was undeniable. There was a bit of a snag early on as Callie had to pick up extra shifts to afford Arizona’s expensive taste during dates, but overall, they got stronger every episode.
Season 7 Featured Calzona’s Cross-Continent Separation
A lot of Milestones Were Stunted By Unexpected Events
- Notable Episodes: 6, 8, 10, 12, 13, 17, 18, 19, and 20
Grey’s Anatomy’s seventh season opens in the aftermath of the mass shooting, which also featured a TV crew filming a piece about Seattle Grace Mercy West’s tragedy. During the documentary, Arizona reveals that she received the Carter Madison Grant to bring pediatric surgery to underdeveloped countries. With her grant, she opened the Namboze Clinic in Africa and left to lead the clinic. Originally, Callie was ecstatic for her girlfriend and even planned to move to Africa with her. But, before they boarded their flight, Arizona admitted that Callie’s mixed feelings about the move soured the experience, and the two split up. Callie takes the breakup hard and hooks up with her best friend, Mark Sloan while trying to heal. Only a few episodes after the breakup, Arizona shows up at Callie’s doorstep, telling her that all she did during her time at Namboze was miss Callie and Seattle. Soon after Arizona’s grand return, Callie reveals she’s pregnant with Mark’s baby.
Callie and Arizona’s Relationship is Strongest in Season 8
Their Love Was Powerful Enough to Overcome the Odds

The Grey’s Anatomy Season 20 finale “Burn It Down” closes out the tense season and teases chaos coming to Grey Sloan Memorial Hospital in Season 21.
- Notable Episodes: 4, 6, 14, 18, 23, and 24
Season 8 featured Callie and Arizona’s relationship at its strongest. The two are happily married and perfectly co-parenting their baby girl with Mark. Everything goes extremely well for the family during Season 8 until the finale.
Season 9 Put Intense Strain on Calzona’s Marriage
Even the Strongest Relationships Suffer In the Wake of Tragedy
- Notable Episodes: 1, 2, 3, 4, 10, 12, 18, 23, and 24
Grey’s Anatomy Season 9 opens immediately after the heartbreaking tragedy befell Seattle Grace Mercy West’s staff. The first episode of Season 9 featured Derek and Callie pulling the plug on Mark, and the next few episodes keep the focus on the survivors of the plane crash, each dealing with severe trauma. That includes Arizona, whose leg got damaged significantly in the accident. Her condition deteriorates drastically, forcing Callie to make the horrifying decision to amputate Arizona’s leg to save her life.
Callie and Arizona Try to Make Their Marriage Work in Season 10
No Matter How Hard Some Couples Try, it’s Impossible to Hold On

Despite previously stepping back from the show, Ellen Pompeo is set to surprise fans with a significant return in Grey’s Anatomy’s 21st season.
- Notable Episodes: 1, 2, 3, 9, 11, 13, 14, 15, 20, and 23
Considering Season 9 ended with Arizona’s infidelity, it’s unsurprising that the first episode of Season 10 features a Calzona fight. The arguing doesn’t last very long, as both surgeons must operate on the same patient. A few episodes into Season 10, Callie kicks Arizona out of the house.
Soon after the split, Callie’s dad reveals that he once cheated on her mom, and they were able to work through their issues. So, Callie lets Arizona move back in, and they keep going to therapy. Despite Arizona’s affair with an intern causing more problems for Calzona and the hospital, the couple tries to move forward, including buying a new house. Season 10 ends with Callie and Arizona deciding to have another baby.
Season 11 Marks the End of Their Marriage
Sometimes There’s No Saving Something Once it’s Broken
- Notable Episodes: 1, 5, 10, 16, 20, and 24
Callie and Arizona Move On and Get Messy in Season 12
There’s No Denying That Moving On Wasn’t Easy For Either of Them

Grey’s Anatomy Season 20 has been a great season for the series, and it makes sure to end with some big surprises and a huge cliffhanger.
- Notable Episodes: 4, 5, 6, 7, 19, 20, 21, 22, 23, and 24
Season 12 features Callie moving on from Arizona with Penny Blake, who first showed up in Season 11 as the doctor who didn’t order a head CT for Derek following his car accident and the doctor who missed the brain bleed that killed him. Naturally, when Callie brings Penny Blake to Meredith’s dinner party, there is a lot of tension, including the line “Perfect Penny killed my husband.” Luckily, the initial shock Callie felt by the revelation passed, and she found happiness with Penny.
Season 13 Says Goodbye to Callie, and Arizona Follows in Season 14
Their Happily Ever After is Left Open to Interpretation
- Notable Episodes: (Season 14) 4, 7, 16, 21, 22, and 24
Grey’s Anatomy Season 13 shut the chapter on Callie Torres following Ramirez’s exit in the Season 12 finale. As such, there was no progress in their relationship. Instead, Arizona moves on with Grey Sloan’s residency advisor, Eliza Minnick. Season 13 and Season 14 do bring little Sofia back into the picture, as she moves back to Seattle. Unfortunately, after a little while of being in Seattle with Arizona, Sofia starts to miss her home in New York and her other mom.
So, at the end of Season 14, when actor Jessica Capshaw left Grey’s Anatomy, the showrunners decided to give Calzona a happier ending. The Season 14 finale features Arizona and Sofia at Jo and Alex’s wedding, getting ready to leave for New York. Not only do Callie and Arizona end up living in the same state, but it’s implied that Callie and Penny broke up. It’s not totally clear whether Callie and Arizona got back together after Season 14. Arizona returned to Grey’s Anatomy in Season 20, but she didn’t bring up Callie once. However, this doesn’t mean that Calzona is in the past for good.